Introduction Semax and Selank are two of the most widely researched neuroactive peptides derived from tuftsin- and melanocortin-related sequences. Both are ultra-short heptapeptides that demonstrate unique interactions with neurotrophic, cognitive, and emotional-regulation pathways. In recent years, researchers have increasingly turned their attention to N-Acetyl Semax and N-Acetyl Selank—structurally modified analogues created by adding an acetyl