EPITHALON 50mg

Epithalon (AEDG) — Research Overview

Introduction

Epithalon, also known as AEDG peptide, Epitalon, or Epithalone, is a synthetic tetrapeptide composed of alanine, glutamic acid, aspartic acid, and glycine. It is modeled after Epithalamin, a naturally occurring pineal gland extract that has been studied for its effects on melatonin production, antioxidant activity, and cellular longevity.Research on Epithalon has suggested potential roles in pineal gland regulation, telomerase activation, oxidative stress reduction, and preservation of retinal and immune system function. Because of its connection to melatonin synthesis and circadian rhythm regulation, Epithalon has been investigated as a candidate for anti-aging, sleep, and neuroprotective studies.

Chemical Characteristics

Other Titles: AEDG Peptide, Epitalon, Epithalone

Research Applications

1. Longevity and Telomere Activity

– Epithalon has been suggested to stimulate telomerase activity, restoring telomere length in aging cells.- In fetal fibroblast models, Epithalon extended telomere length and enabled additional cell divisions beyond the normal Hayflick limit.- Studies of Epithalamin and Epithalon reported lifespan extensions of 11–31% in experimental animals and reduced mortality in aged murine models.

2. Antioxidant and Cellular Protection

– Research indicates Epithalon may reduce intracellular reactive oxygen species (ROS) and protect mitochondrial function in aging oocytes.- Observed benefits include improved mitochondrial membrane potential, increased mtDNA copy numbers, reduced DNA fragmentation, and decreased apoptosis.- Proposed antioxidant effects may include upregulation of endogenous enzymes (superoxide dismutase, catalase, ceruloplasmin).

3. Anti-Aging and Cell Renewal

– Studies suggest Epithalon may suppress Caspase-3–mediated apoptosis, supporting prolonged cell survival.- Upregulation of proliferation markers such as Ki-67 and CD98hc has been reported, indicating enhanced regeneration potential in aged fibroblasts.- Evidence suggests modulation of chromatin and gene expression, with potential activation of previously silenced genetic regions in aged lymphocytes.

4. Retinal and Neurological Effects

– In elderly subjects, Epithalon improved retinal bioelectric responses and preserved retinal structure, with positive clinical outcomes in age-related degeneration.- Its neuroprotective potential may be linked to epigenetic regulation of chromatin and neuronal differentiation pathways.

5. Anti-Mutagenic and Anti-Cancer Research

– Epithalon has been studied for its ability to reduce chromosomal aberrations in accelerated-aging mouse models.- In tumor-bearing mice, Epithalon inhibited metastasis and reduced progression of mammary and ovarian tumors.- These findings suggest possible anti-mutagenic and anti-metastatic actions under research conditions.

6. Endocrine and Melatonin Regulation

– In aging primates, Epithalon restored pineal function and increased melatonin secretion to more youthful levels.- This action suggests a role in circadian rhythm regulation, sleep improvement, and age-related endocrine support.

Conclusion

Epithalon (AEDG peptide) is a synthetic tetrapeptide modeled after a pineal gland extract with wide-ranging research interest in aging, cellular protection, and neuroendocrine regulation. Studies suggest it may influence telomere length, melatonin production, oxidative stress, and tissue regeneration. While findings remain experimental, Epithalon continues to be studied as a potential geroprotective and anti-aging peptide.

Epithalon (Epitalon / Epithalamin) — References

• Khavinson, V. Kh., Morozov, V. G. Peptide regulation of aging: Epithalamin and Epitalon. Biogerontology. 2003;4(3):167–170. https://doi.org/10.1023/A:1024178510674
• Khavinson, V. K., Lin’kova, N. S. Peptides of the pineal gland and aging. Neuro Endocrinology Letters. 2012;33(2):119–126. PMID: 22592198
• Khavinson, V. Kh., Malinin, V. V. Gerontological Aspects of Genome Peptide Regulation. Basel: Karger; 2005. (Comprehensive review on pineal peptides including Epithalamin/Epithalon.)
• Khavinson, V. K., Bondarev, I. E., Butyugov, A. A., Malinin, V. V. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. 2003;135(5):590–592. https://doi.org/10.1023/A:1026051729485
• Khavinson, V. K., Bondarev, I. E., Butyugov, A. A., Malinin, V. V. Epithalon activates chromatin at telomeres and elongates telomeres in human somatic cells. Biochemistry (Moscow). 2004;69(6):757–761. https://doi.org/10.1023/B:BIRY.0000036348.82626.6a
• Khavinson, V. Kh., Linkova, N. S., Dyatlova, A. O., Tarnovskaya, S. I. Peptide Epithalon restores hormone synthesis and secretion in aging primates. Neuro Endocrinology Letters. 2001;22(2): 95–100. PMID: 11335869
• Anisimov, V. N., Khavinson, V. K. Effect of Epithalamin and Epitalon on lifespan and spontaneous tumor incidence in rats. Biogerontology. 2003;4(3):131–134. https://doi.org/10.1023/A:1024167723511
• Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Khavinson, V. K. Inhibitory effect of Epithalon on spontaneous carcinogenesis in female C3H/He mice. Voprosy Onkologii. 2000;46(5): 585–589. PMID: 11065406
• Khavinson, V. K., Mikhailova, O. N., Malinin, V. V., Ryzhak, G. A. Epithalon increases lifespan of fruit flies (Drosophila melanogaster). Mechanisms of Ageing and Development. 2001;122(4): 241–252. https://doi.org/10.1016/S0047-6374(00)00234-7
• Khavinson, V. Kh., Bondarev, I. E. Epithalamin and Epithalon prolong life span of Drosophila melanogaster. Bulletin of Experimental Biology and Medicine. 1997;124(7): 29–32. https://doi.org/10.1007/BF02445949
• Khavinson, V. K., Mikhailova, O. N., Ryzhak, G. A. The pineal peptide preparation Epithalamin increases lifespan and stimulates the immune system in elderly people. Experimental Gerontology. 2000;35(1): 141–152. https://doi.org/10.1016/S0531-5565(00)00071-3
• Anisimov, V. N., Khavinson, V. K. Peptide Epithalon as a geroprotector. Doklady Biological Sciences. 2000;372: 274–277. PMID: 10980720

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